Weitzman E D, Pollak C P
Sleep. 1982;5(4):343-9. doi: 10.1093/sleep/5.4.343.
We studied the effect of flurazepam, a known suppressor of stages 3 and 4 of sleep, on nocturnal sleep patterns and on growth hormone release immediately following sleep onset in normal young adults. Polysomnography and sampling of growth hormone (every 20 min for 26 h) were performed before and after 2 weeks of nightly flurazepam (30 mg, 8 subjects) or placebo (8 subjects) administration. There were no significant changes in growth hormone release in spite of a significant decrease in stage 4 sleep (69%) and total waking time (46%) and an increase in total sleep time (23%) in the drug group. REM sleep was not changed. These results indicate that the normal GH release following sleep onset continues to occur despite stage 4 suppression by pharmacological means.
我们研究了氟西泮（一种已知的睡眠3期和4期抑制剂）对正常年轻成年人夜间睡眠模式以及睡眠开始后立即释放生长激素的影响。在每晚服用氟西泮（30毫克，8名受试者）或安慰剂（8名受试者）2周前后，进行了多导睡眠图监测和生长激素采样（每20分钟一次，共26小时）。尽管药物组的4期睡眠显著减少（69%）、总清醒时间显著减少（46%）以及总睡眠时间增加（23%），但生长激素释放没有显著变化。快速眼动睡眠没有改变。这些结果表明，尽管通过药理学方法抑制了4期睡眠，但睡眠开始后正常的生长激素释放仍会继续发生。
