Denneberg T, Johnell O, Nilsson B E, Wiklund P E
Scand J Urol Nephrol. 1982;16(3):275-8. doi: 10.3109/00365598209179766.
Iliac crest bone biopsies in patients with chronic renal failure with severely disturbed renal function were measured with regard to osteoclast activity and active and inactive osteoid. In none of the 21 patients had hemodialysis been applied. In uremia cases, as earlier demonstrated in hemodialysis cases, the alkaline phosphatase and the parathyroid hormone activity were the best variables for prediction of bone complications. However, none of the laboratory variables or all taken together could predict the type of bone changes. The osteoclast activity was less than in hemodialysis cases indicating that secondary hyperparathyroidism may be less important in the non-hemodialysed cases.
对肾功能严重受损的慢性肾衰竭患者的髂嵴骨活检进行了破骨细胞活性以及活性和非活性类骨质的测定。21例患者均未进行血液透析。与血液透析病例中早期所证实的情况一样，在尿毒症病例中，碱性磷酸酶和甲状旁腺激素活性是预测骨并发症的最佳变量。然而，无论是单个实验室变量还是所有变量综合起来，都无法预测骨变化的类型。破骨细胞活性低于血液透析病例，这表明继发性甲状旁腺功能亢进在未进行血液透析的病例中可能不那么重要。
