Falk V, Lundgren N, Quarfordt L, Arström K
Acta Obstet Gynecol Scand. 1982;61(6):481-6. doi: 10.3109/00016348209156596.
476 cases of Stage I-IV invasive carcinoma of the uterine cervix were treated at the Gynecology Departments in Karlstad and Orebro in 1965-75. 232 (48.7%) were classified Stage I, 198 (85.3%) of them were treated with primary surgery (57 Stage IA and 141 Stage IB). Thirty-four were given primary radiotherapy because of advanced age or co-existing conditions contra-indicating surgery. Of the 141 patients with primary surgery for Stage IB, squamous epithelial carcinoma was established in 88.7% and adenocarcinoma in 11.3%. Surgery revealed lymph node metastases in 13 (9.2%). Postoperative radiotherapy was given to all patients with lymph node metastases, to 3 patients with tumor thrombi in the parametrial vessels, and to 6 in whom surgery had conceivably not been radical. Urinary tract complications requiring reconstructive surgery occurred in 8 (4.0%). The 5-year survival rate with Stage IB was 91.5%, corrected for intercurrent diseases, 5-year survival was 92.8%. Of the 13 with lymph node metastases, 7 were still alive after 5 years. The 5-year survival rate for those without demonstrable lymph node metastases was 94.5%, corrected 96.0%.
1965年至1975年期间，卡尔斯塔德和厄勒布鲁的妇科部门对476例I-IV期子宫颈浸润癌患者进行了治疗。其中232例（48.7%）被归类为I期，其中198例（85.3%）接受了一期手术治疗（57例为IA期，141例为IB期）。34例因年龄较大或存在手术禁忌的并存疾病而接受了一期放疗。在141例接受IB期一期手术的患者中，鳞状上皮癌占88.7%，腺癌占11.3%。手术发现13例（9.2%）有淋巴结转移。所有有淋巴结转移的患者、3例子宫旁血管有肿瘤血栓的患者以及6例手术可能未彻底切除的患者均接受了术后放疗。需要进行重建手术的泌尿系统并发症发生在8例（4.0%）患者中。IB期患者的5年生存率为91.5%，校正并存疾病后，5年生存率为92.8%。在13例有淋巴结转移的患者中，7例在5年后仍然存活。无明显淋巴结转移患者的5年生存率为94.5%，校正后为96.0%。
