Löfberg L, Gustavii B
Acta Obstet Gynecol Scand. 1982;61(6):505-7. doi: 10.3109/00016348209156601.
Attempts were made to obtain skin biopsies from the fetuses of 18 women in the 16th to 21st week of gestation. In four of them the purpose was prenatal diagnosis because of the risk that the fetus might be affected with a severe skin disorder; the remaining women were to undergo elective abortion by hysterotomy. In the first 13 cases the conventional "blind" biopsy procedure was used. Of 71 biopsy specimens obtained with this technique, only one out of every three consisted of skin; the remainder comprised fetal membranes, myometrium, or trophoblast. In one of the diagnostic cases where the "blind" procedure was used, inadvertent removal of tissue specimens from the amniotic sac was probably responsible for the intermittent leakage of amniotic fluid that occurred in this woman from the 26th week of gestation and for the premature delivery in the 33rd week. In the remaining five women (including one for diagnosis), a two-cannula procedure was employed (one cannula for the optic instrument and the other for the biopsy forceps), permitting biopsy of the skin under direct vision. All the biopsy specimens taken by this method consisted of skin.
研究人员尝试从18名处于妊娠第16至21周的女性的胎儿身上获取皮肤活检样本。其中4名女性进行产前诊断的目的是因为胎儿可能患有严重皮肤病；其余女性则计划通过子宫切开术进行选择性流产。在前13例病例中，采用了传统的“盲目”活检程序。用这种技术获取的71个活检样本中，每三个样本只有一个是皮肤组织；其余样本包括胎膜、子宫肌层或滋养层。在使用“盲目”程序的一例诊断病例中，从羊膜囊中意外取出组织样本可能是导致该女性自妊娠第26周起羊水间歇性渗漏以及在第33周早产的原因。在其余5名女性（包括一名用于诊断的女性）中，采用了双套管程序（一个套管用于光学仪器，另一个用于活检钳），从而能够在直视下对皮肤进行活检。通过这种方法获取的所有活检样本均为皮肤组织。
