DeLoach J R, Barton C
Am J Vet Res. 1982 Dec;43(12):2210-2.
The human anti-cancer drug Cytosine arabinoside (ana-C) was encapsulated in canine erythrocytes. When these autologous carrier cells were injected into dogs, the drug was slowly released into plasma. Erythrocyte encapsulation increased the plasma half-life of ara-C in dogs about 50-fold over that of the injected free drug. The whole blood half-life of encapsulated drug was 4.6 days and the elimination constant was 0.150 day-1. Erythrocyte encapsulation holds promise as a drug-delivering technique for treatment of some human and animal diseases, particularly with drugs that are highly toxic or have normally short biological half-life. It also could be used to sustain given concentrations of drugs.
人类抗癌药物阿糖胞苷（阿糖胞苷）被包裹在犬红细胞中。当将这些自体载体细胞注入犬体内时，药物会缓慢释放到血浆中。红细胞包裹使犬体内阿糖胞苷的血浆半衰期比注射游离药物时长约50倍。包裹药物的全血半衰期为4.6天，消除常数为0.150天-1。红细胞包裹作为一种药物递送技术，有望用于治疗某些人类和动物疾病，特别是对于那些毒性高或生物半衰期通常较短的药物。它还可用于维持给定的药物浓度。
