Güllner H G, Lake C R, Gill J R, Lakatua D J
Arch Int Pharmacodyn Ther. 1982 Nov;260(1):78-82.
We examined the effect of dietary potassium depletion on plasma and urinary catecholamines in the rat. Ingestion of a potassium deficient diet for 45 days increased plasma norepinephrine by 80% and plasma epinephrine by 270%. Urinary excretion of epinephrine, norepinephrine and dopamine were not significantly affected by hypokalemia. The results suggest that the increase in plasma catecholamines may be mediated "reflexly" by an accompanying increase in vasodilator agents or may represent a direct "stress" effect of hypokalemia on the release of epinephrine and norepinephrine.
我们研究了饮食中钾缺乏对大鼠血浆和尿儿茶酚胺的影响。摄入缺钾饮食45天可使血浆去甲肾上腺素增加80%，血浆肾上腺素增加270%。低钾血症对肾上腺素、去甲肾上腺素和多巴胺的尿排泄无显著影响。结果表明，血浆儿茶酚胺的增加可能由血管扩张剂伴随增加“反射性”介导，或者可能代表低钾血症对肾上腺素和去甲肾上腺素释放的直接“应激”效应。
