Romanenko A M
Arkh Patol. 1982;44(12):52-8.
A morphological analysis of biopsy specimens from 32 patients with chronic cystitis allowed proliferative and nonproliferative forms of the disease to be distinguished. Chronic cystitis with von Brunn cell nests, cystic and glandular cystitis comprise different stages of the same pathological process which shows no trend for malignization. They may be considered to be the background diseases in the development of the bladder cancer. Vesical leukoplakia tends to malignancy and should be considered as a facultative precancer. Structural-metabolic reorganization in the connective tissue of the submucous layer with impairment of the vessel wall permeability regularly precedes the development of proliferative changes in the epithelial layer of the bladder wall.
对32例慢性膀胱炎患者的活检标本进行形态学分析，得以区分该疾病的增殖性和非增殖性形式。伴有von Brunn细胞巢的慢性膀胱炎、囊性膀胱炎和腺性膀胱炎构成了同一病理过程的不同阶段，该病理过程无恶变倾向。它们可被视为膀胱癌发生发展中的背景疾病。膀胱白斑有恶变倾向，应被视为一种潜在的癌前病变。黏膜下层结缔组织的结构-代谢重组以及血管壁通透性受损通常先于膀胱壁上皮层增殖性改变的发生。
