小鼠白血病病毒感染性DNA的体外合成
In vitro synthesis of infectious DNA of murine leukaemia virus.
作者信息
Rothenberg E, Smotkin D, Baltimore D, Weinberg R A
出版信息
Nature. 1977 Sep 8;269(5624):122-6. doi: 10.1038/269122a0.
DOI:10.1038/269122a0
PMID:71657
Abstract
DNA synthesised in vitro by purified virions of murine leukaemia virus is infectious. Neither RNA nor protein is required for infectivity. Transfection with reverse trancriptase product shows a single-hit dose response and results in the production of complete, infectious virus.
摘要
由纯化的鼠白血病病毒颗粒在体外合成的DNA具有感染性。感染性既不需要RNA也不需要蛋白质。用逆转录酶产物转染显示出单 hit 剂量反应，并导致产生完整的、有感染性的病毒。
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