在清醒的自发性高血压大鼠-脑卒中倾向型（SHR-SP）、自发性高血压大鼠-脑卒中抗性型（SHR-SR）和Wistar-Kyoto（WK）大鼠中，外周脱羧酶抑制剂和5-羟色胺对左旋多巴的脑血流量反应的影响。

CBF response to L-dopa influenced by peripheral decarboxylase inhibitor and serotonin in conscious SHR-SP, SHR-SR and WK rats.

Skolasinska K, Kihara M, Horie R, Yamori Y

Clin Exp Pharmacol Physiol. 1982 Nov-Dec;9(6):631-7. doi: 10.1111/j.1440-1681.1982.tb00834.x.

Abstract

L-Dopa induced a 56% increase in frontal cortical blood flow (fcCBF) one hour after intraperitoneal administration in stroke-prone spontaneously hypertensive rats. The treatment with carbidopa did not alter the magnitude of the response but shortened the response time to half an hour. In stroke-resistant rats and in Wistar Kyoto rats, L-dopa decreased fcCBF. This response was reversed to different degree by carbidopa pretreatment. 2. Serotonin decreased fcCBF in all groups. L-Dopa administered one hour after serotonin resulted in a recovery to the control level in SHR-SR, an increase in fcCBF in WK but the decreased flow in SHR-SP was maintained till the end of the observation time. 3. The data suggest that the stroke-prone rats have an unusual response to L-dopa and that L-dopa and this combination with a peripheral decarboxylase inhibitor may have a beneficial effect on the improvement of cerebral blood flow especially when the pre-existing level of cerebral blood flow is reduced in severe hypertension.

摘要

在易患中风的自发性高血压大鼠腹腔注射左旋多巴1小时后，额叶皮质血流量（fcCBF）增加了56%。卡比多巴治疗并未改变反应幅度，但将反应时间缩短至半小时。在抗中风大鼠和Wistar Kyoto大鼠中，左旋多巴降低了fcCBF。卡比多巴预处理可不同程度地逆转这种反应。2. 血清素使所有组的fcCBF降低。血清素注射1小时后给予左旋多巴，在抗中风自发性高血压大鼠（SHR-SR）中使血流量恢复到对照水平，在Wistar Kyoto大鼠（WK）中使fcCBF增加，但在易患中风的自发性高血压大鼠（SHR-SP）中血流量降低一直持续到观察期结束。3. 数据表明，易患中风的大鼠对左旋多巴有异常反应，并且左旋多巴与外周脱羧酶抑制剂的这种组合可能对改善脑血流量有有益作用，尤其是在严重高血压导致脑血流量预先降低的情况下。