Yoshikawa T, Furukawa Y, Murakami M, Takemura S, Kondo M
Digestion. 1982;25(4):222-9. doi: 10.1159/000198836.
Experimental liver disorders were induced by the use of carbon tetrachloride or D-galactosamine hydrochloride in rats maintained on a vitamin E deficient diet and in rats fed a diet supplemented with vitamin E, and the protective effect of vitamin E on the liver was determined. After exposure to carbon tetrachloride or D-galactosamine hydrochloride the serum levels of transaminases, lysosomal enzyme beta-glucuronidase, and acid phosphatase were elevated, and thiobarbituric acid reactive substances in serum and liver homogenate were also increased. The changes were conspicuous in the vitamin E deficient rats, but were only slight in rats fed a diet supplemented with vitamin E. The results of this study suggest that vitamin E has a protective effect on liver disorders by inhibiting lysosomal enzyme liberation and lipid peroxidation.
在给缺乏维生素E的大鼠以及喂食补充了维生素E的饲料的大鼠使用四氯化碳或盐酸D-半乳糖胺来诱发实验性肝脏疾病后，测定了维生素E对肝脏的保护作用。暴露于四氯化碳或盐酸D-半乳糖胺后，血清转氨酶、溶酶体酶β-葡萄糖醛酸酶和酸性磷酸酶水平升高，血清和肝脏匀浆中的硫代巴比妥酸反应性物质也增加。这些变化在缺乏维生素E的大鼠中很明显，但在喂食补充了维生素E的饲料的大鼠中仅轻微。本研究结果表明，维生素E通过抑制溶酶体酶释放和脂质过氧化对肝脏疾病具有保护作用。
