Parola M, Leonarduzzi G, Biasi F, Albano E, Biocca M E, Poli G, Dianzani M U
Department of Experimental Medicine and Oncology, University of Turin, Italy.
Hepatology. 1992 Oct;16(4):1014-21. doi: 10.1002/hep.1840160426.
Previous studies have shown that alpha-tocopherol (vitamin E) pretreatment of experimental animals can protect against acute liver necrosis induced by carbon tetrachloride. In this study we investigated whether the increase of vitamin E liver content by dietary supplementation influences chronic liver damage and cirrhosis induced by carbon tetrachloride in the rat. Our data indicate that vitamin E supplementation did not interfere with the growth rate of the animals and increased about threefold the liver's content of the vitamin. Vitamin E supplementation significantly reduced oxidative liver damage, but it was not effective in protecting against development of fatty liver and did not interfere with metabolic activation of carbon tetrachloride. Moreover, vitamin E-fed animals showed incomplete but significant prevention of liver necrosis and cirrhosis induced by carbon tetrachloride. This has been shown by means of histological examination, analysis of serum parameters and biochemical evaluation of collagen content. These results show that an increased liver content of vitamin E can afford a significant degree of protection against carbon tetrachloride-induced chronic liver damage and cirrhosis.
先前的研究表明，对实验动物进行α-生育酚（维生素E）预处理可预防四氯化碳诱导的急性肝坏死。在本研究中，我们调查了通过饮食补充增加维生素E在肝脏中的含量是否会影响四氯化碳诱导的大鼠慢性肝损伤和肝硬化。我们的数据表明，补充维生素E不会干扰动物的生长速度，并且使肝脏中该维生素的含量增加了约三倍。补充维生素E可显著减轻肝脏氧化损伤，但对预防脂肪肝的形成无效，且不干扰四氯化碳的代谢活化。此外，喂食维生素E的动物对四氯化碳诱导的肝坏死和肝硬化有不完全但显著的预防作用。这已通过组织学检查、血清参数分析和胶原含量的生化评估得到证实。这些结果表明，肝脏中维生素E含量的增加可对四氯化碳诱导的慢性肝损伤和肝硬化提供显著程度的保护。
