Shiota C, Sasagawa S, Hara K, Ikoma Y, Oshino N
Nihon Yakurigaku Zasshi. 1982 Nov;80(5):375-84.
The possible alteration of central dopaminergic (DA) function, which accompanies the development and persistence of hypertension, was studied in SHRSP by measuring the lisuride-induced locomotor activity and the swimming ability. 1) When administered at a dosage of 50 micrograms/kg, lisuride, a DA agonist, induced significant increases of the locomotor activity in one- and 2-month-old Wistar Kyoto rats (WKY), but not in the 6 month-old rat. Differing from the response of WKY, SHRSP showed only a moderate increase in the locomotor activity at the age of one month (means of systolic blood pressure: 128 mmHg) and apparently no increase at the age of 2 months (176 mmHg). In 6 month-old SHRSP (238 mmHg), hypomotility but not hypermotility was induced by the lisuride administration. 2) Though no significant difference was detected at the age of 4 months, the swimming ability of SHRSP at the age of 8 months was deteriorated significantly as compared to that of WKY, and the impaired swimming performance of SHRSP was improved by the administration of lisuride. These results indicate that some alterations in the synaptic sites of the central DA neuron occurred already at an early stage of the hypertensive development, followed under persistent hypertension by the progressive deterioration of the motor-coordination ability as detected in the swimming ability.
通过测量利苏瑞肽诱导的自发活动和游泳能力，研究了伴有高血压发生和持续存在的中枢多巴胺能（DA）功能的可能改变。1）当以50微克/千克的剂量给药时，DA激动剂利苏瑞肽在1月龄和2月龄的Wistar Kyoto大鼠（WKY）中诱导自发活动显著增加，但在6月龄大鼠中未出现这种情况。与WKY的反应不同，SHRSP在1月龄时（收缩压均值：128 mmHg）自发活动仅适度增加，在2月龄时（176 mmHg）明显未增加。在6月龄的SHRSP（238 mmHg）中，利苏瑞肽给药诱导的是运动减少而非运动增多。2）虽然在4月龄时未检测到显著差异，但与WKY相比，8月龄的SHRSP游泳能力显著下降，利苏瑞肽给药可改善SHRSP受损的游泳表现。这些结果表明，中枢DA神经元突触部位的某些改变在高血压发展的早期阶段就已出现，在持续性高血压状态下，如在游泳能力中检测到的那样，运动协调能力会逐渐恶化。
