Laouari D, Kleinknecht C, Gubler M C, Ravet V, Broyer M
Int J Pediatr Nephrol. 1982 Dec;3(4):263-9.
Several experiments have shown that deterioration of renal parenchyma after reduction of functional mass is affected by the protein content of the diet. The respective role of proteins and that of other nutrients particularly phosphorus which varies with proteins was never clearly separated. Three groups of 9 uremic rats U I, U II, U III, received three diets differing exclusively in their protein content, which was supplied by casein and was respectively 8%, 16% and 32%. Other nutrients were maintained identical, including energy and minerals. Food intake was similar in U I and U II rats and was lower in U III rats. Mortality rate remained closely related to protein intake. Of U III rats, 78% died within 10 weeks and 100% within 15 weeks. Of U II rats, 56% were dead at week 15, and 100% at week 30. Mortality occurred significantly later in U I rats fed the lowest protein diet. Histology of remnant kidneys showed severe glomerular and tubular damage, with no or little calcium deposits despite normal phosphorus diet and frequent hyperphosphoremia. In conclusion, protein intake influences survival by accelerating the renal damage in rats with reduced kidney mass independently of any other nutrient.
多项实验表明，功能性肾单位减少后肾实质的恶化受饮食中蛋白质含量的影响。蛋白质与其他营养素（尤其是随蛋白质含量变化的磷）各自的作用从未得到明确区分。三组各9只尿毒症大鼠（U I、U II、U III）分别接受三种仅蛋白质含量不同的饮食，蛋白质由酪蛋白提供，分别为8%、16%和32%。其他营养素保持相同，包括能量和矿物质。U I组和U II组大鼠的食物摄入量相似，U III组大鼠的食物摄入量较低。死亡率与蛋白质摄入量密切相关。U III组大鼠中，78%在10周内死亡，100%在15周内死亡。U II组大鼠中，56%在第15周死亡，100%在第30周死亡。喂食最低蛋白质饮食的U I组大鼠的死亡时间明显更晚。残余肾脏的组织学检查显示严重的肾小球和肾小管损伤，尽管磷饮食正常且频繁出现高磷血症，但没有或仅有少量钙沉积。总之，蛋白质摄入量通过加速肾单位减少的大鼠的肾损伤来影响生存，且独立于任何其他营养素。
