Lawaetz O, Aritas Y, Blackburn A M, Ralphs D N
Scand J Gastroenterol. 1982 Nov;17(8):1065-72.
In 76 patients before or after different operations for peptic ulceration, the gastric emptying and changes in plasma volume and blood glucose were studied after ingestion of a radionuclide-labelled hypertonic glucose meal. The patients were divided into three clinical categories in accordance with their spontaneous symptoms of dumping after ordinary meals: (a) 26 postoperative patients formed a dumping group, (b) 30 postoperative patients formed a non-dumping group, and (c) 20 preoperative patients formed a control group. A precipitous early phase of gastric emptying was the only specific finding in patients with spontaneous symptoms of dumping. This early fraction of precipitous emptying was not present preoperatively or in patients without symptoms. It is concluded that the excessively rapid delivery of the hypertonic solution into the upper intestine is the primary stimulus leading to the changes in plasma volume and blood glucose observed in the dumping syndrome. The response of the jejunum with regard to the blood glucose and haematocrit rises is considered proportionate to the given stimulus.
在76例接受不同消化性溃疡手术前后的患者中，摄入放射性核素标记的高渗葡萄糖餐后，对其胃排空、血浆容量变化和血糖进行了研究。根据患者普通餐后倾倒综合征的自发症状，将患者分为三个临床类别：(a) 26例术后患者组成倾倒组，(b) 30例术后患者组成非倾倒组，(c) 20例术前患者组成对照组。胃排空的急剧早期阶段是有倾倒综合征自发症状患者的唯一特异性发现。这种急剧排空的早期部分在术前或无症状患者中不存在。得出的结论是，高渗溶液过快进入上段肠道是导致倾倒综合征中观察到的血浆容量和血糖变化的主要刺激因素。空肠对血糖和血细胞比容升高的反应被认为与给定刺激成比例。
