Starup J, Pedersen H
Acta Endocrinol (Copenh). 1978 Dec;89(4):744-52. doi: 10.1530/acta.0.0890744.
This report describes in detail the hormonal and ultrastructural findings in a 21 year old woman with secondary amenorrhoea, who fulfilled all the criteria necessary to establish the diagnosis of resistant ovary syndrome. Ovarian biopsies revealed numerous primordial and primary follicles, which both by light and electron microscopy showed a normal morphology. Nevertheless, the follicles could not be stimulated neither by large doses of human gonadotrophins alone nor by simultaneous administration of cortisone acetate and large doses of human gonadotrophins. The association of a decreased target cell response with increased levels of serum FSH and LH might be explained in different ways. The presence of an inhibitor preventing the normal action of gonadotrophins could not be substantiated, because we did not detect any circulating gonadotrophin antibodies. Furthermore the serum prolactin level was normal.
本报告详细描述了一名21岁继发性闭经女性的激素和超微结构检查结果，该患者符合确立抗卵巢综合征诊断所需的所有标准。卵巢活检显示有大量原始卵泡和初级卵泡，光镜和电镜检查均显示其形态正常。然而，这些卵泡既不能被大剂量的人促性腺激素单独刺激，也不能被同时给予醋酸可的松和大剂量人促性腺激素刺激。血清促卵泡生成素（FSH）和促黄体生成素（LH）水平升高而靶细胞反应降低的关联可能有不同的解释。由于我们未检测到任何循环中的促性腺激素抗体，因此无法证实存在阻止促性腺激素正常作用的抑制剂。此外，血清催乳素水平正常。
