Gilányi M, Simon Z, Kovách A G
Acta Physiol Acad Sci Hung. 1982;59(3):255-63.
Interstitial fluid pressure was measured by Guyton's capsular method in the subcutaneous tissue of rats after a single DOC i.p. injection. Regardless of the dose of DOC, the pressure-time curve showed three phases: latency, decrease and recovery. The maximum drop in pressure and the recovery time were dose-dependent. Maximum decrease in interstitial fluid pressure after 0.25; 0.50; 0.75; 1.00 mg/100 g body wt of DOC was 3.2; 7.1; 9.2 and 10.6 mmHg, respectively. It was found that the recorded pressure response is not exclusively caused by Starling forces. A correlation was found between the pressure decrease and the extracellular potassium loss. The role of potassium in the DOC-induced pressure response was verified by administration of the specific potassium ionophore, valinomycin. Due to the effect of valinomycin, potassium ion transport and, as a consequence, the interstitial pressure response, were accelerated.
单次腹腔注射地塞米松（DOC）后，采用盖顿囊法测量大鼠皮下组织的间质液压力。无论DOC剂量如何，压力-时间曲线均呈现三个阶段：潜伏期、下降期和恢复期。压力的最大降幅和恢复时间与剂量相关。腹腔注射0.25、0.50、0.75、1.00mg/100g体重的DOC后，间质液压力的最大降幅分别为3.2、7.1、9.2和10.6mmHg。研究发现，记录到的压力反应并非仅由斯塔林力引起。压力下降与细胞外钾离子丢失之间存在相关性。通过给予特异性钾离子载体缬氨霉素，证实了钾离子在DOC诱导的压力反应中的作用。由于缬氨霉素的作用，钾离子转运以及随之而来的间质压力反应加速。
