Mulvany M J, Nilsson H, Nyborg N, Mikkelsen E
Acta Physiol Scand. 1982 Nov;116(3):275-83. doi: 10.1111/j.1748-1716.1982.tb07141.x.
We have investigated the extent to which the properties of small arteries from the hindquarters of spontaneously hypertensive rats (SHRs) are consistent with the characteristics of perfused SHR hindquarter preparations (for which the relaxed vascular resistance, the reactivity and the sensitivity are reported to be increased). We have therefore compared the in vitro morphological and pharmacological properties of a femoral resistance vessel (i.d. ca 200 microns) and of the tail artery (i.d. ca 600 microns) from SHRs with those from control Wistar-Kyoto rats (WKYs). When relaxed, for any given wall tension, the internal circumference of the SHR resistance vessels was reduced, but that of the SHR tail artery was normal. When activated with 10 microM noradrenaline, the SHR resistance vessels had an increased calcium sensitivity, but the calcium sensitivity of the SHR tail arteries was normal. However, the maximum response of both types of SHR vessels was such that the vessels would have been able to contract against increased transmural pressure. The noradrenaline sensitivity of the SHR resistance vessels was normal but the SHR tail arteries had a decreased sensitivity. The results suggest that the femoral resistance vessel is in general a better model for the hindquarter vasculature than the tail artery.
我们研究了自发性高血压大鼠（SHR）后肢小动脉的特性与灌注SHR后肢制剂的特征（据报道其舒张血管阻力、反应性和敏感性增加）相符的程度。因此，我们比较了SHR的股阻力血管（内径约200微米）和尾动脉（内径约600微米）与对照Wistar-Kyoto大鼠（WKY）相应血管的体外形态学和药理学特性。舒张时，对于任何给定的壁张力，SHR阻力血管的内周长减小，但SHR尾动脉的内周长正常。用10微摩尔去甲肾上腺素激活时，SHR阻力血管的钙敏感性增加，但SHR尾动脉的钙敏感性正常。然而，两种类型的SHR血管的最大反应是，血管能够抵抗跨壁压力增加而收缩。SHR阻力血管的去甲肾上腺素敏感性正常，但SHR尾动脉的敏感性降低。结果表明，一般而言，股阻力血管比尾动脉更适合作为后肢血管系统的模型。
