Saxén E, Franssila K, Bjarnason O, Normann T, Ringertz N
Acta Pathol Microbiol Scand A. 1978 Nov;86A(6):483-6. doi: 10.1111/j.1699-0463.1978.tb02073.x.
Histologic slides of 696 cases of thyroid cancer reported to the national cancer registries of Finland, Iceland, Norway and Sweden were reviewed by 5 Nordic pathologists in order to determine the observer variation between the pathologists, as well as the reproducibility of the WHO classification of thyroid tumours. In 58% of the cases all observers agreed upon the diagnosis and in 82% at least three of them agreed. The observer disagreement was lowest for papillary carcinoma (7%) and highest for follicular carcinoma (27%). The corresponding figures for anaplastic and medullary carcinomas were 18% and 23%, respectively. The most common diverging diagnosis for cases finally interpreted as papillary carcinoma was follicular carcinoma, and for cases finally interpreted as follicular carcinoma, a benign thyroid lesion. The results of the present study clearly indicate the necessity of having all cases reviewed by the same pathologist or group of pathologists in order to obtain reliable results for comparative studies.
芬兰、冰岛、挪威和瑞典国家癌症登记处报告的696例甲状腺癌组织学切片由5名北欧病理学家进行了复查，以确定病理学家之间的观察者差异，以及世界卫生组织甲状腺肿瘤分类的可重复性。在58%的病例中，所有观察者对诊断意见一致，在82%的病例中至少有三人意见一致。观察者分歧在乳头状癌中最低（7%），在滤泡状癌中最高（27%）。间变性癌和髓样癌的相应数字分别为18%和23%。最终被诊断为乳头状癌的病例最常见的不同诊断是滤泡状癌，而最终被诊断为滤泡状癌的病例，最常见的不同诊断是良性甲状腺病变。本研究结果清楚地表明，为了获得可靠的比较研究结果，所有病例必须由同一位病理学家或一组病理学家进行复查。
