Larsen T E, Grude T H
Acta Pathol Microbiol Scand A. 1978 Nov;86A(6):513-22. doi: 10.1111/j.1699-0463.1978.tb02078.x.
A selected series of 669 primary malignant melanomas of the skin, stage I, was studied. The series includes 86 lentigo maligna melanomas, 259 superficial spreading malignant melanomas, 194 nodular malignant melanomas and 130 unclassifiable malignant melanomas. The tumour cell type was classified and the tumour cell pigmentation, the cellular atypia and the mitotic count was graded. The relation of these four tumour cell features to each other and to the tumour type was studied by X2tests. The prognostic value of these features in relation to the total series as well as to each tumour type was also examined. The most common features were mixed cellularity, little pigment, moderate atypia and low mitotic count. Most of these tumours were superficial spreading malignant melanomas. A good prognosis was related to spindle-shaped tumour cells, marked pigmentation, slight atypia and few mitoses. A bad prognosis was related to epithelioid tumour cells, little pigment, marked atypia and many mitoses. Variations of lentigo maligna melanoma tended to be more benign while variations of nodular malignant melanoma tended to be more malignant than the average. A superficial spreading malignant melanoma might vary in either direction.
对一组选定的669例I期原发性皮肤恶性黑色素瘤进行了研究。该组包括86例恶性雀斑样痣黑色素瘤、259例浅表扩散性恶性黑色素瘤、194例结节性恶性黑色素瘤和130例无法分类的恶性黑色素瘤。对肿瘤细胞类型进行了分类，并对肿瘤细胞色素沉着、细胞异型性和有丝分裂计数进行了分级。通过卡方检验研究了这四种肿瘤细胞特征之间以及与肿瘤类型之间的关系。还检查了这些特征相对于整个系列以及每种肿瘤类型的预后价值。最常见的特征是细胞混合性、色素少、异型性中等和有丝分裂计数低。这些肿瘤大多数是浅表扩散性恶性黑色素瘤。预后良好与梭形肿瘤细胞、明显色素沉着、轻度异型性和少量有丝分裂有关。预后不良与上皮样肿瘤细胞、色素少、明显异型性和大量有丝分裂有关。恶性雀斑样痣黑色素瘤的变异往往更良性，而结节性恶性黑色素瘤的变异往往比平均情况更恶性。浅表扩散性恶性黑色素瘤可能向任何一个方向变化。
