Dorfman L J, Cummins K L, Abraham G S
Muscle Nerve. 1982;5(9S):S148-53.
We have estimated the distribution of conduction velocities (DCV) of large myelinated fibers in the median nerves of 10 normal subjects and a patient with amyotrophic lateral sclerosis (ALS) who had a de-efferented hand, using three different computer-based methods: a 2CAP method, which tests both motor and sensory nerve fibers; and 2MAP and CMAP methods, which test only the alpha motor fibers. The magnitudes of the parameters DCVmax, DCVmean, DCVpeak, and DCVrange all were very similar in the two motor estimations, but all were significantly higher (P less than 0.001 in each case) in the mixed nerve estimates; the differences presumably represent the properties of the faster-conducting sensory fiber population. The 2CAP DCV from the de-efferented nerve resembled those from normal mixed nerve. Compared with DCV analysis, conventional measures of maximal motor and sensory CV were found to be relatively poor indices of the conduction properties of their respective large, myelinated, nerve fiber populations.
我们使用三种不同的基于计算机的方法，估计了10名正常受试者以及一名患有肌萎缩侧索硬化症（ALS）且手部去传入神经的患者正中神经中大有髓纤维的传导速度（DCV）分布：一种是2CAP方法，可检测运动和感觉神经纤维；还有2MAP和CMAP方法，仅检测α运动纤维。在两种运动估计中，参数DCVmax、DCVmean、DCVpeak和DCVrange的大小都非常相似，但在混合神经估计中，所有这些参数均显著更高（每种情况P均小于0.001）；这些差异可能代表了传导速度更快的感觉纤维群体的特性。去传入神经的2CAP DCV与正常混合神经的相似。与DCV分析相比，发现传统的最大运动和感觉CV测量相对而言是其各自大的有髓神经纤维群体传导特性的较差指标。
