Sordo J C, Arroyo M, Macarulla J M, Fedriani J R, Marino A
Rev Esp Fisiol. 1982 Dec;38(4):427-31.
The effect of tobacco and alcohol on the delta-amino levulinic dehydratase (ALA-D) activity and lead level in blood is studied in a population of workers with or without exposure to lead due to their work. The lead level in the blood of workers without exposure is about 15.9 +/- 1.7 micrograms/100 ml and is unaltered by sex. The ALA-D level for men and women is 289.7 +/- 15 U/100 ml and 255.9 +/- 10 U/100 ml respectively, the difference being due mainly to the smaller hematocrit for women. Without lead exposure smoking moderately does not change the ALA-D or the lead level, whereas alcoholic drink consumption increases the lead level but does not affect the ALA-D activity. When both factors concur the ALA-D activity decreases, while the lead level increases. With lead exposure, however, neither the ALA-D activity nor the lead level undergoes any change, with of without smoking and drinking, since the values have been completely altered by the exposure. A close relationship between ALA-D activity and lead level in blood has been found in each case.
对一组因工作接触或未接触铅的工人，研究了烟草和酒精对δ-氨基乙酰丙酸脱水酶（ALA-D）活性及血铅水平的影响。未接触铅的工人血铅水平约为15.9±1.7微克/100毫升，且不受性别影响。男性和女性的ALA-D水平分别为289.7±15 U/100毫升和255.9±10 U/100毫升，差异主要是由于女性的血细胞比容较小。在未接触铅的情况下，适度吸烟不会改变ALA-D或血铅水平，而饮酒会使血铅水平升高，但不影响ALA-D活性。当两种因素同时存在时，ALA-D活性降低，而血铅水平升高。然而，在接触铅的情况下，无论吸烟和饮酒与否，ALA-D活性和血铅水平均无变化，因为这些值已因接触铅而完全改变。在每种情况下，均发现ALA-D活性与血铅水平之间存在密切关系。
