Klaus W, Güttler K
Adv Myocardiol. 1982;3:571-5. doi: 10.1007/978-1-4899-5561-6_54.
The influence of carbocromen (chromonar) on both functional and some metabolic parameters of isolated guinea pig hearts was tested over a broad concentration range and with different exogenous substrates. As revealed from a shift of the myocardial respiratory quotient, carbocromen (in the upper coronary active concentration range) induced an increased glucose utilization at the expense of FFA oxidation. Theoretically, this may indicate a relative reduction of myocardial oxygen demand, but the therapeutic relevance of this observation still remains obscure, as an additional exogenous FFA supply may override this biochemical carbocromen effect.
在很宽的浓度范围内并使用不同的外源性底物，测试了卡波罗孟（色满卡林）对离体豚鼠心脏的功能和一些代谢参数的影响。从心肌呼吸商的变化可以看出，卡波罗孟（在冠状动脉活性较高的浓度范围内）导致葡萄糖利用增加，而脂肪酸氧化减少。从理论上讲，这可能表明心肌需氧量相对降低，但这一观察结果的治疗意义仍不明确，因为额外供应外源性脂肪酸可能会抵消卡波罗孟的这种生化效应。
