Bergleiter R
Zentralbl Gynakol. 1982;104(24):1605-12.
Nuclear size and ratio between DNA and nucleus were measured in 787 normal, pseudo-dyskaryotic and dyskaryotic cells of superficial and intermediary layers obtained from condylomatous lesions as well as from cases of atypical metaplasia and slight dysplasia, following Feulgen staining of the cytological specimens. All cell types occurred at different periods of time, as was observed in a longitudinal-section study. This, together with the data measured, was likely to suggest the biphasic nature of changes in cell nuclei, in that initially functional nuclear oedema (pseudo-dyskaryosis) was followed by differentiation towards the dyskaryotic cell. These processes were found to occur first to superficial cells and second to intermediary cells. In the phase of intermediary dyskaryosis the quantity of DNA was increased with significance by polyploidisation. All six cell populations differed from one another with significance by nuclear surface.
对787个取自湿疣病变、非典型化生及轻度发育异常病例的表层和中层的正常、假双核细胞及双核细胞进行了福尔根染色后，测量了细胞核大小以及DNA与细胞核的比例。如在纵向切片研究中观察到的那样，所有细胞类型均出现在不同的时间段。这一点，连同所测得的数据，可能表明细胞核变化具有双相性，即最初是功能性核水肿（假双核），随后向双核细胞分化。发现这些过程首先发生在表层细胞，其次发生在中层细胞。在中层双核阶段，DNA的数量通过多倍体化显著增加。所有六个细胞群体的核表面均存在显著差异。
