Halmy L, Nyakas C, Walter J
Acta Physiol Acad Sci Hung. 1982;59(4):341-7.
The effect of mazindol on feeding behaviour was investigated in rats fasted for 24 hours. They were then given mazindol i.p. and placed in a new environment. The effect of the drug on the disappearance of 3H-noradrenaline (3H-NA) from various parts of the brain after injection into the cerebral ventricles was also investigated. Mazindol was more potent in suppressing feeding behaviour than in reducing food intake, indicating that a number of aspects of feeding behaviour may be more sensitive indices of the anorectic effect of a drug than food intake per se. Mazindol, in a dose of 30 mg/kg, accelerated the disappearance of 3H-NA from the medial hypothalamus but not from other areas of the brain, suggesting that the drug has a locus-specific action on cerebral noradrenaline metabolism.
在禁食24小时的大鼠中研究了马吲哚对摄食行为的影响。然后给它们腹腔注射马吲哚，并置于新环境中。还研究了该药物对脑室注射后3H-去甲肾上腺素（3H-NA）从大脑各部位消失的影响。马吲哚在抑制摄食行为方面比减少食物摄入量更有效，这表明摄食行为的多个方面可能比食物摄入量本身更能敏感地反映药物的厌食作用。30mg/kg剂量的马吲哚加速了3H-NA从中脑下丘脑的消失，但未加速其从大脑其他区域的消失，这表明该药物对脑去甲肾上腺素代谢具有位点特异性作用。
