McCall M A, Tieman D G, Hirsch H V
Brain Res. 1982 Nov 4;250(2):301-8. doi: 10.1016/0006-8993(82)90424-3.
In kittens, but not in adult cats, depriving one eye of pattern vision by suturing the lids shut (monocular deprivation or MD) for one week reduces the proportion of binocular units in the visual cortex. A sensitivity of cortical units in adult cats to MD can be produced by infusing exogenous monoamines into the visual cortex. Since LSD interacts with monoamines, we have examined the effects of chronic administration of LSD on the sensitivity to MD for cortical cells in adult cats. Cats were assigned randomly to one of four conditions: MD/LSD, MD/No-LSD, No-MD/LSD, No-MD/No-LSD. An osmotic minipump delivered either LSD or the vehicle solution alone during a one-week period of MD. The animals showed no obvious anomalies during the administration of the drug. After one week the response properties of single units in area 17 of the visual cortex were studied without knowledge of the contents of the individual minipumps. With the exception of ocular dominance, the response properties of units recorded in all animals did not differ from normal. In the control animals (MD/No-LSD, No-MD/LSD, No-MD/No-LSD) the average proportion of binocular cells was 78%; similar to that observed for normal adult cats. However, in the experimental animals, which received LSD during the period of MD, only 52% of the cells were binocular. Our results suggest that chronic intraventricular administration of LSD affects either directly or indirectly the sensitivity of cortical neurons to MD.
在小猫中，而非成年猫中，通过缝合眼睑使其一只眼睛丧失模式视觉（单眼剥夺或MD）一周，会降低视觉皮层中双眼神经元的比例。通过向成年猫的视觉皮层注入外源性单胺，可以使成年猫的皮层神经元对MD产生敏感性。由于麦角酸二乙胺（LSD）与单胺相互作用，我们研究了长期给予LSD对成年猫皮层细胞对MD敏感性的影响。将猫随机分配到四种情况之一：MD/LSD、MD/无LSD、无MD/LSD、无MD/无LSD。在为期一周的MD期间，渗透微型泵单独输送LSD或溶剂溶液。给药期间动物未表现出明显异常。一周后，在不知道各个微型泵内容物的情况下，研究了视觉皮层17区单个神经元的反应特性。除了眼优势外，所有动物记录的神经元反应特性与正常情况无差异。在对照动物（MD/无LSD、无MD/LSD、无MD/无LSD）中，双眼细胞的平均比例为78%；与正常成年猫观察到的比例相似。然而，在MD期间接受LSD的实验动物中，只有52%的细胞是双眼的。我们的结果表明，长期脑室内给予LSD直接或间接影响皮层神经元对MD的敏感性。
