Guerre-Millo M, Challier J C, Rey E, Nandakumaran M, Richard M O, Olive G
Dev Pharmacol Ther. 1982;4(3-4):158-72. doi: 10.1159/000457405.
The influence of plasma protein binding on the maternofetal transfer of diazepam was studied in the perfused human placental lobule. Substitution of buffered salt perfusate in both maternal and fetal circuits for a perfusate with plasma proteins did not alter diazepam transfer significantly. Diazepam placental uptake was shown to be important in perfusion, with both types of perfusates. Comparison with the less liposoluble and less protein-bound benzodiazepine, fosazepam, revealed a marked difference in placental uptake but not in maternofetal transfer. In incubation studies, the kinetics of placental uptake confirmed this difference.
在灌注的人胎盘小叶中研究了血浆蛋白结合对安定母婴转运的影响。在母体和胎儿循环中，用含血浆蛋白的灌注液替代缓冲盐灌注液，并未显著改变安定的转运。在两种类型的灌注液中，安定的胎盘摄取在灌注过程中都很重要。与脂溶性较低且蛋白结合较少的苯二氮䓬类药物福沙西泮相比，胎盘摄取存在显著差异，但母婴转运无差异。在孵育研究中，胎盘摄取动力学证实了这种差异。
