Bertino J S, Kliegman R M, Myers C M, Blumer J L
Dev Pharmacol Ther. 1982;4(3-4):205-15. doi: 10.1159/000457409.
The effect of double volume exchange transfusion on the pharmacokinetics of gentamicin was studied in 7 neonates undergoing eight transfusions. The procedures were performed an average of 9.6 h following the previous dose of drug and required an average of 0.91 h to complete. Exchange transfusion decreased serum gentamicin concentrations by 18.5 +/- 4.2% and increased the elimination rate for gentamicin by 31.8%. Serum concentrations obtained an average of 3.3 h following the procedure showed a rebound increase in concentration compared to that obtained just at the end of the transfusion (2 cases), no change (1 case) or a decrease compared with the immediate posttransfusion period (5 cases). The results observed in the late posttransfusion period were found to be inversely related (r = -0.78) to the number of doses received by the patient prior to the procedure. A one-compartment pharmacokinetic model was found to be adequate in predicting the amount of drug removed by the procedure while a two-compartment model best described the posttransfusion alteration in elimination kinetics.
在7名接受了8次换血的新生儿中，研究了双倍容量交换输血对庆大霉素药代动力学的影响。这些操作平均在先前一剂药物给药后9.6小时进行，平均需要0.91小时完成。交换输血使血清庆大霉素浓度降低了18.5±4.2%，并使庆大霉素的消除率提高了31.8%。与输血刚结束时相比，在操作后平均3.3小时测得的血清浓度显示浓度有回升（2例）、无变化（1例）或与输血后即刻相比降低（5例）。发现在输血后期观察到的结果与患者在操作前接受的剂量数呈负相关（r = -0.78）。发现一室药代动力学模型足以预测该操作去除的药物量，而二室模型最能描述输血后消除动力学的变化。
