脑池内注射蛙皮素对大鼠半胱胺诱导的十二指肠溃疡的影响。

The effect of intracisternally administered bombesin on cysteamine-induced duodenal ulcers in rats.

作者信息

Hernandez D E, Adcock J W, Nemeroff C B, Prange A J

出版信息

Eur J Pharmacol. 1982 Oct 22;84(3-4):205-9. doi: 10.1016/0014-2999(82)90203-5.

Abstract

Cysteamine (420 mg/kg s.c.) increased gastric acid secretion in rats 3-6 h post-injection; duodenal pH fell from 6.0 +/- 0.2 (S.E.M.) at 0 time to 2.2 +/- 0.3 at 12 h. A high (60-80%) incidence of duodenal ulcerations was observed 18 h after cysteamine injection. Intracisternal (i.c.) administration of bombesin (1 microgram) significantly inhibited both cysteamine-induced increases in gastric acid secretion and the development of duodenal ulcers. This effect of bombesin was dose-dependent and appears to be relatively specific since i.c. neurotensin (1 or 30 micrograms) was not cytoprotective. Peripheral cholinergic (muscarinic) blockade with atropine methylbromide (10 mg/kg i.p.) was as effective as i.c. bombesin (1 microgram) in inhibiting cysteamine-induced gastric hypersecretion and duodenal ulcers.

摘要

半胱胺（420毫克/千克，皮下注射）在注射后3 - 6小时增加大鼠胃酸分泌；十二指肠pH值从0时的6.0±0.2（标准误）在12小时时降至2.2±0.3。半胱胺注射18小时后观察到十二指肠溃疡的高发生率（60 - 80%）。脑池内（i.c.）注射蛙皮素（1微克）显著抑制半胱胺诱导的胃酸分泌增加和十二指肠溃疡的发生。蛙皮素的这种作用是剂量依赖性的，并且似乎相对特异，因为脑池内注射神经降压素（1或30微克）没有细胞保护作用。用甲基溴化阿托品（10毫克/千克，腹腔注射）进行外周胆碱能（毒蕈碱）阻断在抑制半胱胺诱导的胃酸分泌过多和十二指肠溃疡方面与脑池内注射蛙皮素（1微克）一样有效。