Colpaert F C
Eur J Pharmacol. 1982 Oct 22;84(3-4):229-31. doi: 10.1016/0014-2999(82)90208-4.
Two groups of rats were trained to discriminate 0.04 mg/kg of fentanyl from saline (drug-saline discrimination) or from 0.02 mg/kg of fentanyl (dose-dose discrimination). The ED50 of naloxone for antagonizing the discriminative effects of 0.04 mg/kg fentanyl was 0.05 and 0.0062 mg/kg, respectively. This 8.1 fold difference in naloxone reversibility suggests that dose-dose discrimination yields higher pharmacological specificity than the commonly used drug-saline discrimination.
两组大鼠接受训练，以区分0.04毫克/千克的芬太尼与生理盐水（药物-生理盐水辨别）或0.02毫克/千克的芬太尼（剂量-剂量辨别）。纳洛酮拮抗0.04毫克/千克芬太尼辨别效应的半数有效剂量（ED50）分别为0.05和0.0062毫克/千克。纳洛酮可逆性的这8.1倍差异表明，剂量-剂量辨别比常用的药物-生理盐水辨别产生更高的药理学特异性。
