Mossberg B, Björkander J, Afzelius B A, Camner P
Eur J Respir Dis. 1982 Nov;63(6):570-8.
Tracheobronchial mucociliary clearance was studied in six patients with immunoglobulin deficiency. They inhaled a test aerosol of 6 microns teflon particles tagged with 99mTc, after which external measurements of the retention of test particles in the lungs were made during 2 h. Four younger patients with common variable immunodeficiency and severe symptoms of airway infections all had a markedly slow clearance. In one of these cases clearance was measured again after 6 months of adequate medical treatment and was found much improved. Two older patients with less severe immunoglobulin deficiency (one with selective IgA deficiency and one with transient hypogammaglobulinemia), and with a history of less severe airway infections, had normal clearance. The results indicate that chronic infection of the airways, if severe enough, will damage the mucociliary transport system, but that this damage is not necessarily irreversible. Ciliary ultrastructure was investigated by electron microscopy in two of the younger patients with slow clearance, and was found to be normal.
对6例免疫球蛋白缺乏患者的气管支气管黏液纤毛清除功能进行了研究。他们吸入了一种用99mTc标记的6微米聚四氟乙烯颗粒的测试气雾剂，之后在2小时内对肺部测试颗粒的滞留情况进行了外部测量。4例患有常见可变免疫缺陷且有严重气道感染症状的年轻患者，其清除功能均明显缓慢。其中1例在经过6个月充分的药物治疗后再次测量清除功能，发现有明显改善。2例免疫球蛋白缺乏程度较轻的老年患者（1例为选择性IgA缺乏，1例为暂时性低丙种球蛋白血症），且气道感染病史较轻，其清除功能正常。结果表明，气道的慢性感染如果足够严重，会损害黏液纤毛转运系统，但这种损害不一定是不可逆的。对2例清除功能缓慢的年轻患者进行了电子显微镜检查，发现其纤毛超微结构正常。
