Kyrge P K, Eller A K, Timpmann S K, Séppet E K
Fiziol Zh SSSR Im I M Sechenova. 1982 Oct;68(10):1431-7.
Repeated determination of post--exercise glycogen repletion in liver, heart, white and red skeletal muscles of intact and adrenalectomized rats with or without the administration of dexamethasone and sucrose revealed that a glycogen supercompensation effect depends on the availability of glucocorticoids. Other factors which considerably modify the effect of glucocorticoids on glycogen synthesis, are the molecular properties of the mechanism through which the hormone actualizes its biological effect. The stimulating effect of dexamethasone on glycogen synthesis in the liver and heart muscle of adrenalectomized rats is blocked by cycloheximide. This suggests that the role of glucocorticoids in the regulation of post--exercise glycogen synthesis depends upon cycloheximide--sensitive protein synthesis.
在完整的和肾上腺切除的大鼠中，无论是否给予地塞米松和蔗糖，对其肝脏、心脏、白色和红色骨骼肌运动后糖原补充情况进行反复测定，结果显示糖原超补偿效应取决于糖皮质激素的可利用性。其他显著改变糖皮质激素对糖原合成作用的因素，是激素实现其生物学效应所通过机制的分子特性。地塞米松对肾上腺切除大鼠肝脏和心肌中糖原合成的刺激作用被环己酰亚胺阻断。这表明糖皮质激素在运动后糖原合成调节中的作用取决于对环己酰亚胺敏感的蛋白质合成。
