免疫反应调节中的关键抗原决定簇。
Key antigenic determinants in regulation of the immune response.
作者信息
Turkin D, Sercarz E E
出版信息
Proc Natl Acad Sci U S A. 1977 Sep;74(9):3984-7. doi: 10.1073/pnas.74.9.3984.
Abstract
The immune response to beta-galactosidase (beta-D-galactoside galactohydrolase; EC 3.2.1.23)is characterized by a wave of early help followed by a wave of suppression to a subsequent in vitro challenge with galactosidase-fluorescein. A cyanogen bromide peptide of beta-galactosidase, CB2, mimics the suppression seen with the enzyme. It is time dependent, carrier specific, and anti-theta sensitive; however, this suppression is not preceded by a wave of help. It is possible that CB2 cannot stimulate helpers, and is only able to activate suppressor cells. These data indicate that one small region of an antigen, capable of activating suppressors, can nullify the positive effect induced in helper T cells reactive with other epitopes on beta-galactosidase. Key determinants on macromolecules may in this way be influential in regulating the immune response to the entire antigen molecule.
摘要
对β-半乳糖苷酶（β-D-半乳糖苷半乳糖水解酶；EC 3.2.1.23）的免疫反应的特征是，先是一阵早期的辅助反应，随后是一阵抑制反应，以应对随后用半乳糖苷酶-荧光素进行的体外攻击。β-半乳糖苷酶的一种溴化氰肽CB2，模拟了该酶所产生的抑制作用。它具有时间依赖性、载体特异性且对抗θ敏感；然而，这种抑制作用之前并没有一阵辅助反应。有可能CB2无法刺激辅助细胞，而只能激活抑制细胞。这些数据表明，抗原的一个小区域，能够激活抑制细胞，就可以消除在与β-半乳糖苷酶上其他表位反应的辅助性T细胞中诱导产生的阳性效应。大分子上的关键决定簇可能以这种方式影响对整个抗原分子的免疫反应的调节。
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