Glaninger J
Fortschr Med. 1982 Sep 16;100(35):1605-11.
The sudden hearing impairment sensu stricture constitutes an otologic emergency, the genesis of which is still a mystery. The one-sided, reduced auditory sensitivity (labyrinthine deafness, sensorineural lesion) occurs unexpectedly and, more often than not, in good general condition with the remaining otologic diagnosis showing almost no anomalies. The cause for this impairment is considered to be a cochlear malfunctioning of the microcirculation with ensuing hypoxia/anoxia in stria vascularis and in Corti's organ, which is caused by a change in the circulation qualities of the blood (hemagglutination, aggregation of thrombocytes etc.) sometimes in the wake of a viral infection. Although sometimes spontaneous remissions of the sense of hearing occur in subjects suffering from a sudden hearing impairment - with no prognostic parameter, however - it is of utmost importance to start therapy immediately after the first symptoms have occurred. Therapeutic measures should aim at a reactivation of the impaired microcirculation in order to eliminate the lack of oxygen in the areas concerned. In addition to the indispensable internal treatment, it is recommended to use dextran of low molecular weight to attain hemodilution as well as aggregation inhibitors to improve the rheologic qualities of the blood.
严格意义上的突发性听力损失构成耳科急症,其病因仍是个谜。单侧听力敏感度下降(迷路性耳聋,感觉神经性病变)出乎意料地发生,而且往往在一般状况良好时出现,其余耳科诊断几乎无异常。这种听力损失的病因被认为是微循环的耳蜗功能障碍,继而导致血管纹和柯蒂器缺氧/无氧,这有时是在病毒感染后血液流动性质改变(血凝、血小板聚集等)所致。尽管突发性听力损失患者有时会出现听力自发恢复——但没有预后参数——然而在出现最初症状后立即开始治疗至关重要。治疗措施应旨在使受损的微循环重新激活,以消除相关区域的缺氧状况。除了必不可少的内科治疗外,建议使用低分子右旋糖酐进行血液稀释,并使用聚集抑制剂改善血液流变学性质。