多个视网膜母细胞瘤中存在相似的染色体异常。

Similar chromosomal abnormalities in several retinoblastomas.

作者信息

Kusnetsova L E, Prigogina E L, Pogosianz H E, Belkina B M

出版信息

Hum Genet. 1982;61(3):201-4. doi: 10.1007/BF00296442.

Abstract

The study of banded chromosomes of nine sporadic unilateral retinoblastomas revealed near diploid karyotypes with multiple numerical and (or) structural abnormalities in all tumors. An identical marker i(6p) was noted in cells of the modal class of six retinoblastomas. Extra copies of the short arm of chromosome 6 were observed in seven tumors: +i(6p) in 6 and +6q-in one. Less regular but repeated findings were a loss of one sex chromosome, and markers 1p+ and 17q+. The structure of these markers was not identical in different tumors. Abnormalities of chromosome 13 were not observed in tumor cells, nor in blood lymphocytes stimulated by PHA.

摘要

对9例散发性单侧视网膜母细胞瘤的带型染色体研究显示，所有肿瘤的核型均接近二倍体，伴有多个数目和（或）结构异常。在6例视网膜母细胞瘤的众数类细胞中发现了相同的标记i(6p)。在7个肿瘤中观察到6号染色体短臂的额外拷贝：6例为+i(6p)，1例为+6q-。不太规律但反复出现的发现是一条性染色体缺失，以及标记1p+和17q+。这些标记在不同肿瘤中的结构并不相同。在肿瘤细胞以及PHA刺激的血液淋巴细胞中均未观察到13号染色体异常。