Ivankovic S
Int J Biol Res Pregnancy. 1982;3(3):99-102.
Malignant tumors are the second most common cause of death in children 0 to 15 years old. The typical organotropism of tumors in children is different than in adults aged 45-60 years. Due to the short induction periods, as well as the typical distribution of tumors, it is conceivable that various agents (chemicals, viruses) may induce carcinogenic effects during the prenatal life-span. It has been confirmed experimentally that certain chemicals, e.g., ethylnitrosourea, are potent prenatal carcinogens. Further, it is important to consider the especially high sensitivity of the fetus for chemical agents; this enhanced sensitivity is a major point of issue when discussing prenatal carcinogenesis. Results and conclusions obtained from prenatal carcinogenicity experiments should provide a basis for elucidating causes of cancer in children.
恶性肿瘤是0至15岁儿童中第二大常见死因。儿童肿瘤典型的器官嗜性与45至60岁的成年人不同。由于诱导期短以及肿瘤的典型分布，可以想象各种因素（化学物质、病毒）可能在胎儿期诱导致癌作用。实验已证实某些化学物质，如乙基亚硝基脲，是强效的产前致癌物。此外，必须考虑到胎儿对化学物质具有特别高的敏感性；在讨论产前致癌作用时，这种增强的敏感性是一个主要问题。产前致癌性实验获得的结果和结论应为阐明儿童癌症病因提供依据。
