新型碳青霉烯类化合物OA - 6129组抗生素的研究。II. 体外评估。

Studies on the OA-6129 group of antibiotics, new carbapenem compounds. II. In vitro evaluation.

作者信息

Sakamoto M, Kojima I, Okabe M, Fukagawa Y, Ishikura T

出版信息

J Antibiot (Tokyo). 1982 Oct;35(10):1264-70. doi: 10.7164/antibiotics.35.1264.

DOI:10.7164/antibiotics.35.1264

Abstract

The OA-6129 group of antibiotics, new carbapenem compounds, had relatively potent antimicrobial activities against Gram-positive and Gram-negative bacteria. Synergism of compound OA-6129A in combination with conventional beta-lactam antibiotics was observed in antimicrobial activity against beta-lactamase producers such as Proteus vulgaris GN 76 and Citrobacter freundii GN 346. The new carbapenem compounds were slightly superior to PS-5 in stability to kidney homogenates of various animal species.

摘要

OA - 6129组抗生素，即新型碳青霉烯类化合物，对革兰氏阳性菌和革兰氏阴性菌具有相对较强的抗菌活性。在针对诸如普通变形杆菌GN 76和弗氏柠檬酸杆菌GN 346等β-内酰胺酶产生菌的抗菌活性中，观察到化合物OA - 6129A与传统β-内酰胺类抗生素联合使用具有协同作用。这些新型碳青霉烯类化合物在对各种动物物种肾脏匀浆的稳定性方面略优于PS - 5。