Blackwell B
J Clin Psychiatry. 1982 Nov;43(11 Pt 2):14-21.
Despite controversy about the significance of compliance, the difficulty of studying the issue, and the poor quality of research in this area, there is a consensus from the literature and patient self-reports that side effects reduce compliance. About a fifth of depressed patients refuse drugs, and half of those in treatment drop out because of specific side effects and/or general attitudes toward treatment. Strategies to decrease side effects and improve compliance include plasma monitoring, once-a-day regimens, educational techniques, and basing the choice of tricyclic compounds or second generation drugs on individual patient needs.
尽管对于依从性的重要性存在争议、研究该问题存在困难且该领域研究质量不佳，但文献和患者自我报告达成的共识是，副作用会降低依从性。约五分之一的抑郁症患者拒绝服药，接受治疗的患者中有一半因特定副作用和/或对治疗的总体态度而退出治疗。减少副作用并提高依从性的策略包括血浆监测、每日一次给药方案、教育技巧，以及根据个体患者需求选择三环类化合物或第二代药物。
