Campbell D G, Shields M B, Smith T R
Am J Ophthalmol. 1978 Sep;86(3):317-24. doi: 10.1016/0002-9394(78)90232-5.
We found that the spectrum of essential iris atrophy (progressive essential iris atrophy, Chandler's syndrome, and the Cogan-Reese syndrome) began as a corneal endothelial degeneration, which, with ectopic endothelial membrane overgrowth over an open angle, followed by contraction of this membrane and further growth onto the iris, accounted for all aspects of the syndrome. The contractile membrane caused the synechiae, the glaucoma, the corectopia, the ectropion uveae, the occasional iris nodules, and the iris atrophy. Thus we found this disease to be primarily of the cornea, and only secondarily of the iris. The results of this study led us to propose a new designation for this spectrum: primary proliferative endothelial degeneration.
我们发现，原发性虹膜萎缩（进行性原发性虹膜萎缩、钱德勒综合征和科根-里斯综合征）的病变过程始于角膜内皮变性，随着房角处异位内皮膜增生，随后该膜收缩并进一步生长至虹膜，这解释了该综合征的所有症状。收缩膜导致了虹膜粘连、青光眼、瞳孔异位、虹膜睫状体外翻、偶尔出现的虹膜结节以及虹膜萎缩。因此，我们发现这种疾病主要起源于角膜，其次才累及虹膜。本研究结果促使我们为这一系列病症提出一个新的命名：原发性增殖性内皮变性。
