Changes in unmyelinated fibers including sympathetic postganglionic fibers of a skin nerve after peripheral neuroma formation.

Conduction velocities of unmyelinated fibers and proportions of postganglionic fibers which can be activated from the lumbar sympathetic trunk were determined for the superficial peroneal nerve of the cat's hindlimb. The nerve was either left intact (4 control experiments) or cut and ligated peripherally 6-245 days before the experiments so that neuromata developed (15 experiments). Additionally, 3 control experiments were performed on the sural nerve. Our findings are that about 20-30% of all unmyelinated fibers in intact skin nerves are postganglionic sympathetic fibers. This percentage of postganglionic axons, which can be activated from the preganglionic side, decreases to 0-7% 100 days or more after the nerve section. In intact skin nerves the conduction velocity of the afferent unmyelinated fibers is greater (mean +/- 1 S.D.: 0.88 +/- 0.17 m/s) than that of postganglionic axons (0.69 +/- 0.14 m/s). The conduction velocities in both types of axons decrease by 25-30% in nerves with peripheral neuroma. This occurs largely during the first 15 days following the nerve section described.