精氨酸和去甘氨酰胺赖氨酸加压素对中枢诱发的升压反应的减弱作用。

Attenuation by arginine- and desglycinamide-lysine-vasopressin of a centrally evoked pressor response.

作者信息

Versteeg C A, Bohus B, de Jong W

出版信息

J Auton Nerv Syst. 1982 Sep;6(2):253-62. doi: 10.1016/0165-1838(82)90055-8.

Abstract

Arginine8-vasopressin (AVP) administered in a lateral cerebral ventricle attenuated the pressor response evoked by electrical stimulation of the mesencephalic reticular formation (MRF) in urethane-anesthetized rats. The blockade appeared to be dose-dependent in the range of 3-25 ng. The maximal effect was a 40% reduction of the pressor response. Desglycinamide9-lysine8-vasopressin (DG-LVP) exerted a similar effect on the pressor response. Both AVP and DG-LVP failed to affect basal blood pressure upon intraventricular administration. It is suggested that centrally acting neuropeptides related to vasopressin affect brain mechanisms involved in the regulation of blood pressure.

摘要

在侧脑室注射精氨酸8 - 血管加压素（AVP）可减弱在氨基甲酸乙酯麻醉大鼠中由电刺激中脑网状结构（MRF）诱发的升压反应。在3 - 25纳克范围内，这种阻断作用似乎呈剂量依赖性。最大效应是升压反应降低40%。去甘氨酰胺9 - 赖氨酸8 - 血管加压素（DG - LVP）对升压反应产生类似作用。脑室内注射AVP和DG - LVP均未影响基础血压。提示与血管加压素相关的中枢作用神经肽会影响参与血压调节的脑机制。