Smith D G
Am J Phys Anthropol. 1978 Aug;49(2):257-63. doi: 10.1002/ajpa.1330490214.
Exceptions have been cited which rule against the simple autosomal recessive hypothesis for the transmission of susceptibility to infection with Australia antigen (HBsAg). An attempt is made here to present a genetic model for a complex segregation analysis of a new and unique set of data to test this hypothesis. Regression techniques were used to estimate in four populations, age and sex-specific penetrance levels and the frequency of the gene whose product is hypothesized to be HBsAg. While the genetic hypothesis was not in general supported, observed deviations and their possible causes are discussed.
有人提出了一些例外情况，这些情况与澳大利亚抗原（HBsAg）感染易感性传递的简单常染色体隐性假说相悖。本文试图提出一个遗传模型，用于对一组全新且独特的数据进行复杂的分离分析，以检验这一假说。采用回归技术在四个群体中估计年龄和性别特异性的外显率水平，以及其产物被假定为HBsAg的基因频率。虽然总体上遗传假说未得到支持，但对观察到的偏差及其可能原因进行了讨论。
