David I B, Buck J R, Filler R M
J Pediatr Surg. 1982 Oct;17(5):494-500. doi: 10.1016/s0022-3468(82)80096-1.
Gangrenous and perforated appendicitis was reviewed in 300 pediatric patients. Those with only gangrene generally had a benign course regardless of whether antibiotic therapy was used. However, patients with local perforation or generalized peritonitis had a high incidence of infective complications if they were not treated with antibiotics. Children treated with ampicillin, gentamicin, and clindamycin had markedly fewer wound infections and abscesses and were able to tolerate a diet and go home sooner than those receiving ampicillin and/or gentamicin.
对300例小儿坏疽性及穿孔性阑尾炎病例进行了回顾性研究。单纯坏疽的患儿，无论是否使用抗生素治疗，病情通常都较为良性。然而，局部穿孔或弥漫性腹膜炎的患儿若未接受抗生素治疗，感染性并发症的发生率很高。接受氨苄西林、庆大霉素和克林霉素治疗的患儿伤口感染及脓肿明显较少，且比接受氨苄西林和/或庆大霉素治疗的患儿能更快耐受饮食并出院。
