Hulse G, Coleman G, Nicholas J, Greenwood K
J Reprod Fertil. 1982 Nov;66(2):451-6. doi: 10.1530/jrf.0.0660451.
Immature, 32-day-old rats were treated with PMSG. Stress consisting of 180 min immobilization administered during the period of the preovulatory LH surge resulted in the blockage of ovulation. The anti-ovulatory action of stress was effectively antagonized by the administration of naloxone hydrochloride shortly before the application of the stress, suggesting that the ovulation block by stress is mediated by endogenous opioids known to be elevated during stress. Blockage of ovulation by 180 min immobilization stress occurred only in rats from one of the two laboratory strains tested, suggesting that stress resistance is, at least in part, genetically determined.
对32日龄的未成熟大鼠注射孕马血清促性腺激素（PMSG）。在排卵前促黄体生成素（LH）激增期间进行180分钟的固定应激，导致排卵受阻。在施加应激前不久给予盐酸纳洛酮，可有效拮抗应激的抗排卵作用，这表明应激导致的排卵受阻是由应激期间已知会升高的内源性阿片类物质介导的。180分钟固定应激导致的排卵受阻仅发生在测试的两个实验室品系之一的大鼠中，这表明应激抗性至少部分是由基因决定的。
