Greener Y, Martis L, Indacochea-Redmond N
J Toxicol Environ Health. 1982 Sep;10(3):385-96. doi: 10.1080/15287398209530261.
The toxicity of cyclohexanone, used as a solvent cement in polyvinyl chloride medical devices, was assessed in Wistar and Gunn rats. The Gunn rat was used because it has a negligible activity of UDP glucuronosyltransferase toward bilirubin and certain other aglycones. Cyclohexanone was administered iv for 28 consecutive days to Wistar and Gunn rats in two doses (50 and 100 mg/kg), using solutions containing 0.25 and 0.50 g per 100 ml, respectively, at a constant volume of 20 mg/kg. Saline (0.9% NaCl) was used as the control. Daily observations for signs of toxicity showed no adverse effects in Wistar or Gunn rats injected with either dose. Daily weight changes of control and test animals were similar. Ophthalmologic examinations revealed no treatment-related structural lesions. No adverse effects were noted when the data from the hemogram or clinical chemistry parameters were evaluated. Gross pathological and histopathologic assessment showed no alterations due to cyclohexanone treatment. Urinary excretions of total and glucuronide conjugates of cyclohexanol were similar for Wistar and Gunn rats; less than 1% was excreted as free cyclohexanone and cyclohexanol. It is concluded that the Gunn rat is capable of forming glucuronides of cyclohexanol and that cyclohexanone at these doses has a negligible toxic potential.
在Wistar大鼠和Gunn大鼠中评估了用作聚氯乙烯医疗器械溶剂黏合剂的环己酮的毒性。选用Gunn大鼠是因为其对胆红素及某些其他苷元的UDP葡萄糖醛酸基转移酶活性可忽略不计。分别使用每100 ml含0.25 g和0.50 g的溶液，以20 mg/kg的恒定体积，连续28天对Wistar大鼠和Gunn大鼠静脉注射环己酮，剂量分别为50和100 mg/kg。使用生理盐水（0.9% NaCl）作为对照。每日观察毒性迹象发现，注射任一剂量的Wistar大鼠或Gunn大鼠均未出现不良反应。对照动物和受试动物的每日体重变化相似。眼科检查未发现与治疗相关的结构损伤。评估血常规或临床化学参数数据时未发现不良反应。大体病理学和组织病理学评估显示，环己酮处理未造成改变。Wistar大鼠和Gunn大鼠的环己醇总尿排泄量和葡萄糖醛酸结合物尿排泄量相似；以游离环己酮和环己醇形式排泄的量不到1%。结论是，Gunn大鼠能够形成环己醇的葡萄糖醛酸结合物，并且这些剂量的环己酮具有可忽略不计的潜在毒性。
