Picchioni A L, Chin L, Gillespie T
J Toxicol Clin Toxicol. 1982 Jul;19(5):433-44. doi: 10.3109/15563658208992498.
Studies in rats were performed to evaluate the effect of sorbitol on the antidotal efficacy of activated charcoal against four test drugs and to investigate the influence of storage upon the antidotal effect of activated charcoal-sorbitol suspension. The antidotal potency of activated charcoal was not diminished by sorbitol solution 70% w/v. In fact, it was enhanced by the sorbitol solution, as indicated by greater decrease in peak tissue drug concentration, compared to the effect produced by activated charcoal in aqueous suspension. Furthermore, storage of activated charcoal in sorbitol for as long as 1 year did not reduce the antidotal-efficiency of the absorbent.
进行了大鼠实验，以评估山梨醇对活性炭针对四种受试药物的解毒效果的影响，并研究储存对活性炭-山梨醇混悬液解毒效果的影响。70%（w/v）山梨醇溶液不会降低活性炭的解毒效力。事实上，山梨醇溶液增强了活性炭的解毒效力，与活性炭水混悬液产生的效果相比，组织药物峰值浓度的下降幅度更大就表明了这一点。此外，活性炭在山梨醇中储存长达1年并不会降低吸附剂的解毒效率。
