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类固醇疗法治疗近期麻风病“安静性神经麻痹”。25例患者的研究报告。

Steroid therapy in recent "quiet nerve paralysis" in leprosy. Report of a study of twenty-five patients.

作者信息

Srinivasan H, Rao K S, Shanmugam N

出版信息

Lepr India. 1982 Jul;54(3):412-9.

PMID:7176532
Abstract

Nerve trunks may "quietly" get paralysed in a proportion of leprosy patients without going through a stage of acute or subacute neuritis. A study of 25 male patients with quiet paralysis of 57 nerves shows that such paralysis, which may be complete or incomplete, can occur in any type of leprosy and may involve any nerve trunk. Steroid therapy for six months reversed the motor paralysis to a satisfactory extent in about 75% of the nerves. Recovery rate was higher in nerves other than the ulnar nerve, and when paralysis was incomplete or of short duration. There was no recurrence of paralysis after stopping steroid therapy. Except for mooning of the face noticed in two patients, no serious side effects attributable to prolonged steroid therapy occurred in the subjects included in this trial.

摘要

在一部分麻风病患者中,神经干可能会“悄然”麻痹,而不经历急性或亚急性神经炎阶段。一项对25名男性患者共57条神经的“隐匿性”麻痹的研究表明,这种麻痹可能是完全性的,也可能是不完全性的,可发生于任何类型的麻风病,且可能累及任何神经干。为期6个月的类固醇治疗使约75%的神经运动麻痹得到了令人满意的改善。尺神经以外的神经以及不完全麻痹或病程较短时,恢复率更高。停止类固醇治疗后未出现麻痹复发。除两名患者出现面部虚胖外,该试验纳入的受试者未出现因长期类固醇治疗导致的严重副作用。

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引用本文的文献

1
Electro-physiological evaluation of nerves during reactions in leprosy.麻风病反应期神经的电生理评估
J Neurol. 1996 Jul;243(7):530-5. doi: 10.1007/BF00886875.