慢性锂预处理对大鼠脑毒蕈碱受体调节的影响。

The effect of chronic lithium pretreatment on rat brain muscarinic receptor regulation.

作者信息

Levy A, Zohar J, Belmaker R H

出版信息

Neuropharmacology. 1982 Nov;21(11):1199-201. doi: 10.1016/0028-3908(82)90180-0.

Abstract

The effect of two weeks of lithium (Li) pretreatment on up and down regulation of muscarinic receptors in rat brain was measured in two groups of rats. After two weeks of feeding 0.2% LiCL in ground pellets, one group of rats was injected with atropine (3 mg/kg daily for 5 days) and another group with diisopropyl fluorophosphate, a cholinesterase inhibitor (1.2 mg/kg). Li pretreatment completely abolishes the significant 23% rise in QNB binding induced by atropine but does not prevent the significant 16% decline in QNB binding induced by DFP. These results suggest that chronic Li pretreatment prevents supersensitivity but does not prevent subsensitivity of rat brain muscarinic receptors.

摘要

在两组大鼠中测量了锂（Li）预处理两周对大鼠脑中毒蕈碱受体上调和下调的影响。在以含0.2%LiCl的颗粒饲料喂养两周后，一组大鼠注射阿托品（每天3mg/kg，共5天），另一组注射胆碱酯酶抑制剂氟磷酸二异丙酯（1.2mg/kg）。锂预处理完全消除了阿托品诱导的QNB结合显著升高23%的情况，但不能阻止氟磷酸二异丙酯诱导的QNB结合显著下降16%。这些结果表明，慢性锂预处理可预防大鼠脑毒蕈碱受体的超敏反应，但不能预防其低敏反应。