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[煤矿工人尘肺支气管肺泡灌洗回收的细胞群体]

[Cell populations recovered by bronchoalveolar lavage in pneumoconiosis of coal miners].

作者信息

Voisin C, Wallaert B, Ramon P, Gosselin B, Aerts C

出版信息

Rev Inst Hyg Mines (Hasselt). 1982;37(2):77-88.

PMID:7178758
Abstract

Studying the cellular products obtained by broncho-alveolar lavage in 81 patients, 77 coal-miners and 4 other subjects exposed to silicotic risks of various origin, the authors could demonstrate the interest of this new method of exploring the peripheral lung tissues. In 57 cases of usual pneumoconiosis and controls matched for the smoking habits, the repartition of the different cellular types was quite similar. On the contrary, the authors observed an increase of the lymphocytes in three cases of accelerated elution of the pneumoconiosis. Moreover various modifications were noticed in cases with morbid associations as conectivitis, sarcoïdosis, allergic alveolitis, and primitive diffuse interstitial fibrosis as well. At the moment they were collected, the alveolar macrophages of the subjects to dust showed the same properties of vitality and adherence capacity as the controls. After 24 hours of survival their vitality and bacterial activity on staphylococcus aureus was clearly diminished.

摘要

通过对81例患者(77名煤矿工人和4名其他有不同来源矽肺风险的受试者)支气管肺泡灌洗获得的细胞产物进行研究,作者能够证明这种探索外周肺组织新方法的价值。在57例普通尘肺病例以及与吸烟习惯相匹配的对照组中,不同细胞类型的分布相当相似。相反,作者在3例尘肺加速洗脱病例中观察到淋巴细胞增多。此外,在合并有结缔组织炎、结节病、过敏性肺泡炎和原发性弥漫性间质纤维化等疾病的病例中也注意到了各种变化。在采集时,接触粉尘受试者的肺泡巨噬细胞显示出与对照组相同的活力和黏附能力特性。存活24小时后,它们对金黄色葡萄球菌的活力和细菌活性明显降低。

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