Fischer G, Hori A, Ulbrich R, Rath W
Rontgenblatter. 1982 Dec;35(12):438-43.
Cloverleaf skull anomaly was diagnosed sonographically and in the fetogram, together with concomitant chondrodystrophy. This resulted in an indication for intentional abortion in the 29th week. Consequently, this rare form of skull monstrosity could be examined pathologico-anatomically for the first time in a very early stage of foetal development. Contrary to the widely held opinion that the reason for such hideous malformation is a hydrocephalus internus due to a deformation of the skull base, we found a practically negligible hydrocephalus, although the cloverleaf skull had already developed in a very marked manner. Hence, this case contradicts the generally adopted formal pathogenetic interpretation of cloverleaf skull monstrosity.
超声检查和胎儿影像诊断出了三叶草颅骨异常，并伴有软骨发育不良。这导致在孕29周时进行了人工流产。因此，这种罕见的颅骨畸形在胎儿发育的极早期就首次接受了解剖病理学检查。与普遍认为这种可怕畸形的原因是由于颅底变形导致的脑内积水的观点相反，我们发现虽然三叶草颅骨已经非常明显地发育，但脑积水实际上可以忽略不计。因此，这个病例与通常采用的三叶草颅骨畸形的形式病因学解释相矛盾。
