Pasik T, Pasik P
Acta Biol Acad Sci Hung. 1982;33(2-3):277-88.
Golgi and electron microscopic observations of the neostriatum of macaque monkeys reveal the presence of thin axons of extrinsic origin which produce a profuse arborization of very fine beaded branches. The varicosities contain pleomorphic synaptic vesicles, and may form strongly asymmetric axospinous synapses. Immunocytochemical methods utilizing an unlabeled antibody against serotonin followed by peroxidase-antiperoxidase complex and further histochemical visualization demonstrate that some elements conforming to the above description exhibit specific immunoreactivity. Relatively few of the labeled profiles form synapses and did so with small dendritic spines. In these cases the membrane specializations are strongly asymmetric. The neuropil also contains many unstained elements of similar morphology. The findings provide the morphologic features of serotoninergic axons in the neostriatum. Their properties may be shared by other monoaminergic afferents. It is suggested that serotonin is released as a neurotransmitter from synapsing boutons, and as a neuromodulator from non-synapsing varicosities. This distinction may correlate with the serotonin receptors 1 and 2 which apparently are responsible for excitatory and inhibitory actions respectively.
对猕猴新纹状体进行的高尔基体染色和电子显微镜观察显示，存在起源于外部的细轴突，这些轴突会产生大量带有非常细的串珠状分支的分支。膨体含有多形性突触小泡，并可能形成强烈不对称的轴棘突触。利用抗血清素未标记抗体、随后的过氧化物酶 - 抗过氧化物酶复合物以及进一步的组织化学显色的免疫细胞化学方法表明，一些符合上述描述的成分表现出特异性免疫反应性。相对较少的标记结构形成突触，并且是与小的树突棘形成突触。在这些情况下，膜特化是强烈不对称的。神经毡中还含有许多形态相似的未染色成分。这些发现提供了新纹状体中血清素能轴突的形态学特征。它们的特性可能与其他单胺能传入纤维共有。有人提出，血清素作为神经递质从突触小体释放，作为神经调质从非突触膨体释放。这种区别可能与血清素受体1和2相关，这两种受体显然分别负责兴奋和抑制作用。
